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Next Generation Sequencing analysis of the global expression profiling in bone marrow derived macrophages response to porcine circovirus type 2.

ABSTRACT: To know the influences of PCV2 infection on macrophage phenotype, we examined the expression profiling of global genes in PCV2 infected-BMDMs by RNA-seq. The results revealed that expression of 369 genes were greater than twofold in PCV2 infected-BMDMs relative to their expression levels in control cells. In addition, the expression of 201 genes were lower than in PCV2-infected macrophages compared to that of control cells . Among these genes, we found that PCV2 infection strikingly induced expression of a subset of M1-associated genes, whereas decreased expression of multiple M2-associated genes, indicating that PCV2 infection likely reprograms the macrophage transcription phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE171721 | GEO | 2021/07/20

REPOSITORIES: GEO

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