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Developmental chromatin programs determine oncogenic competence in melanoma [RNA-seq II]

ABSTRACT: Transcriptional profile of 3xKO dox melanocytes and 3xKO ATAD2 dox melanocytes

ORGANISM(S): Homo sapiens

PROVIDER: GSE172030 | GEO | 2021/04/15

REPOSITORIES: GEO

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Developmental chromatin programs determine oncogenic competence in melanoma [Cut&Run]

Project description:We perfomed Cut&Run for ATAD2, MYC and SOX10 in 3xKO ATAD2 dox melanocytes and 3xKO dox melanocytes. We used 10'000 cells per condition and the protocol was performed as in Skene et al., 2018. We could show that, in the 3xKO ATAD2 dox melanocytes, ATAD2, MYC and SOX10 have common targets. Many of those targets belong to a developmental signature typical of the neural crest and to the MAPK pathway.

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