Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172180 | GEO | 2021/04/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [10X Genomics]

Project description:Using 10X Genomics we identified B cells with a plasmablasts signature (based on CD38, CD27 and PRDM1 expression) and extract these cells to assign them to our Smart-seq analysis run in parallel.

2021-04-16 | GSE172179 | GEO

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [Smart-seq]

Project description:Using Smart-seq2 single cell sequencing we reported that plasmablasts from dengue-infected individuals separate into 4 distinct clusters with distinct function.

2021-04-16 | GSE172176 | GEO

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

Project description:Clinically important broadly reactive B cells evolve during multiple infections. The phenotype and function of B cells re-activated after secondary infection is different compared to B cells activated after a primary infection. Here we studied CD27highCD38high plasmablasts from patients with a primary or secondary dengue virus infection. Three transcriptionally and functionally distinct plasmablast clusters were identified. The largest cluster 0/1 was plasma cell-related and contained cells coding for virus serotype cross-reactive antibodies of the IgG1 isotype, consistent with memory B cell activation during an extrafollicular response. In contrast, cells in clusters 2 and 3 expressed low levels of antibody genes and high levels of genes associated with oxidative phosphorylation, EIF2 pathway and mitochondrial dysfunction. Clusters 2 and 3, which we name T cell-dependent plasmablasts, showed a transcriptional footprint of T cell help, in line with activation from either naÃƒÂ¯ve B cells or memory B cells. Our results contribute to the understanding of the parallel B cell activation events that occur in humans after natural primary and secondary infection.

| EGAS00001005258 | EGA

CD27<sup>hi</sup>CD38<sup>hi</sup> plasmablasts are activated B cells of mixed origin with distinct function.

Project description:Clinically important broadly reactive B cells evolve during multiple infections, with B cells re-activated after secondary infection differing from B cells activated after a primary infection. Here we studied CD27highCD38high plasmablasts from patients with a primary or secondary dengue virus infection. Three transcriptionally and functionally distinct clusters were identified. The largest cluster 0/1 was plasma cell-related, with cells coding for serotype cross-reactive antibodies of the IgG1 isotype, consistent with memory B cell activation during an extrafollicular response. Cells in clusters 2 and 3 expressed low levels of antibody genes and high levels of genes associated with oxidative phosphorylation, EIF2 pathway, and mitochondrial dysfunction. Clusters 2 and 3 showed a transcriptional footprint of T cell help, in line with activation from naive B cells or memory B cells. Our results contribute to the understanding of the parallel B cell activation events that occur in humans after natural primary and secondary infection.

| S-EPMC8169951 | biostudies-literature

Distinct Function for ASCL1 and NEUROD1 in Pulmonary Neuroendocrine Tumors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-21 | E-GEOD-69398 | biostudies-arrayexpress

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

Project description:CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

| PRJNA722298 | ENA

14q32 recombinations deregulating BCL11B mark a distinct Mixed Phenotype Leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-05 | GSE162283 | GEO

Genomic classification and identification of the cell of origin of pediatric mixed phenotype acute leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-18 | GSE112561 | GEO

Transcriptomic analysis of cell-of-origin CNS neuroblastoma, FOXR2 activated

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-07 | GSE270666 | GEO

Replication origin selection organizes meiotic recombination

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-02-20 | E-GEOD-53921 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data