Transcriptomics

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RNA-sequencing of human pluripotent stem-cell derived endothelial cells under control and Wnt-activating conditions


ABSTRACT: Endothelial cells (ECs) in the central nervous system (CNS) acquire specialized barrier properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of endothelial barrier function. We used human pluripotent stem cell (hPSC)-derived endothelial progenitor cells to profile the EC response to Wnt activation using multiple strategies, including the small molecule GSK-3 inhibitor CHIR 99021, and the CNS-derived ligands Wnt7a and Wnt7b.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173206 | GEO | 2021/11/10

REPOSITORIES: GEO

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