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MicroRNAome of highly metastatic and non-metastatic human breast cell lines

ABSTRACT: MicroRNAs are noncoding, endogenous small RNAs that regulate target genes by cleavage of the targeted mRNA or translational repression. We investigated the microRNAome using 2-color microarrays in a highly invasive human breast cancer cell line, MDA-MB-231 (sub line 4175) and a non-invasive breast epithelial cell line, MCF10A. We found 13 miRNAs that were up-regulated and 9 were down-regulated significantly in 4175 cells (p <0.05, fold change >2) compared with MCF10A cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE17350 | GEO | 2009/07/28

SECONDARY ACCESSION(S): PRJNA119063

REPOSITORIES: GEO

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