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Non-programmed dissemination of cancer cell clusters induce malignant properties through Integrin beta 1 activation

ABSTRACT: We found that epithelial cluster recruiment soluble fibronectin and then activating beta1 Integrin induce epithelial-mesenchymal transition and enhance cancer cells’ malignant after cell dissemination. Non-programmed dissemination of cluster cells triggers ERK cascade and then accelerate tumor growth and metastasis. Our finding reveals that cell cluster plays a vital role in the non-programmed dissemination of breast cancer cells’ metastasis, offering a potential new therapeutic target for metastasis patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173538 | GEO | 2022/12/31

REPOSITORIES: GEO

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Depletion of beta1 integrins in triple negative breast cancer cells causes extensive alterations in gene expression profiles

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Project description:PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

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