Non-programmed dissemination of cancer cell clusters induce malignant properties through Integrin beta 1 activation
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ABSTRACT: We found that epithelial cluster recruiment soluble fibronectin and then activating beta1 Integrin induce epithelial-mesenchymal transition and enhance cancer cells’ malignant after cell dissemination. Non-programmed dissemination of cluster cells triggers ERK cascade and then accelerate tumor growth and metastasis. Our finding reveals that cell cluster plays a vital role in the non-programmed dissemination of breast cancer cells’ metastasis, offering a potential new therapeutic target for metastasis patients.
ORGANISM(S): Homo sapiens
PROVIDER: GSE173538 | GEO | 2022/12/31
REPOSITORIES: GEO
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