Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNAseq analysis of kidneys from RNLS knockout mice with chronic kidney disease treated with RNLS peptide encapsulated in mesonanoparticles

ABSTRACT: We compared transcriptome profiles of kidneys from RNLS KO mice treated with RNLS peptide RP81 in mesonanoparticle (RP81-MNP) or with empty MNP (control). Our study provided some molecular mechanism of how RNLS peptide protected kidney from cisplatin-induced CKD.

ORGANISM(S): Mus musculus

PROVIDER: GSE174010 | GEO | 2021/12/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell RNAseq analysis of kidneys from Wild Type and RNLS knockout control mice and mice with chronic kidney disease

Project description:We compared transcriptome profiles of WT kidneys with that of RNLS KO kidneys. We also compared transcriptome profiles of healthy kidneys to CKD kidneys. Our study represents the first detailed transcriptome analysis of kidneys from mice with cisplatin-induced chronic kidney disease and provides the dissection of renalase functions.

2021-12-16 | GSE174013 | GEO

Single-cell RNAseq analysis of kidneys from RNLS knockout mice with chronic kidney disease treated with RNLS peptide encapsulated in mesonanoparticles

Project description:Single-cell RNAseq analysis of kidneys from RNLS knockout mice with chronic kidney disease treated with RNLS peptide encapsulated in mesonanoparticles

| PRJNA727851 | ENA

Renalase Alleviates Left Ventricular Hypertrophy and Fibrosis in a Chronic Kidney Disease Mouse Model

Project description:RNLS global knockout (KO) and wild-type (WT) mice were used in the present study to establish a long-term CKD model (up to 18 weeks post-surgery) via 2-step 5/6 Nx, and we observed the role of RNLS by over-expressing it using a cardiac-specific adeno-associated virus (AAV). 2-weeks post-surgery, we injected AAV9-cTnT-RNLS or vector to WTor KO CKD mice by tail vein and the hearts were harvested at week 18. Then RNA-sequencing (RNA-seq) analysis was performed to explore the underlying molecular mechanism.

2022-05-01 | GSE199350 | GEO

MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease [RNA-seq]

Project description:Chronic kidney disease (CKD) complicates cisplatin-based chemotherapy of cancer patients. Here we investigate microRNA (miRNA)-regulated transcriptomic activity to unveil biological processes associated with cisplatin-induced kidney injury. Implementing chimeric-eCLIP-seq approach to a mouse model for cisplatin-induced CKD, we identify direct pairs of miRNA and their target messenger RNA in the injured kidney. We find a dedicated transcriptomic program directed by a group of miRNAs that alter metabolic pathways centered on mitochondria in the injured kidneys. Specifically, cisplatin-induced miRNA, miR-429-3p suppresses the mitochondria pathway that catalyzes branched-chain amino acid (BCAA), eventually leading to lipid peroxidation-dependent cell death, called ferroptosis. Thus, the identification of miRNA-429-3p-mediated stimulation of ferroptosis suggests a therapeutic potential for BCAA pathway modulation in ameliorating CKD and cisplatin-associated nephrotoxicity.

2023-11-01 | GSE242808 | GEO

MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease [miRNA-seq]

2023-11-01 | GSE242807 | GEO

MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease [CLIP-seq]

2023-11-01 | GSE242806 | GEO

Transcriptome analysis of kidneys of cisplatin-induced AKI model

Project description:This study was aimed to investigate the role and underlying mechanism of TRPM2 in cisplatin nephrotoxicity. Cisplatin-induced acute kidney injury (AKI) model was established in WT and TRPM2-KO mice. The transcriptome profiling of the kidneys of WT and TRPM2-KO mice treated with cisplatin was compared to find differentially expressed gene which may be related to TRPM2 on cisplatin nephrotoxicity.

2023-03-30 | GSE203584 | GEO

Distinct Transcriptosomes of Kidneys of Chronic Kidney Disease Mice with Time Restricted Feeding

Project description:To further character the significant changes in renal gene expression after time restricted feeding (TRF) treatment in CKD mice,RNA-sequencing was performed in the kidneys.

2021-11-24 | GSE189377 | GEO

Transcriptome analysis of kidneys of cisplatin-induced AKI model

Project description:Transcriptome analysis of kidneys of cisplatin-induced AKI model

| PRJNA841498 | ENA

Gene expression profiles in isolated proximal tubules and whole kidneys of rats after cisplatin-administration

Project description:To clarify the effects of cisplatin (cis-diamminedichloroplatinum II, CDDP) on the gene expression profiles in renal proximal tubules, microarray analyses were carried out using total RNA samples isolated from microdissected proximal tubules and whole kidneys. The molecular events underlying acute kidney injury (AKI) in the proximal tubules of rats with cisplatin-induced nephrotoxicity were successfully clarified with 17,000 transcripts.

2013-12-24 | GSE37133 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data