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Single-Cell RNA-Sequencing of potassium antimony tartrate (PAT)-treated PBMCs with p53-V272M derived from an AML patient

ABSTRACT: The goals of this study are to compare transcriptome of p53-V272M rescued by PAT in primary AML PBMCs

ORGANISM(S): Homo sapiens

PROVIDER: GSE174125 | GEO | 2022/05/02

REPOSITORIES: GEO

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Transcriptome analysis of mutant p53 rescued by potassium antimony tartrate (PAT)

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Single-Cell RNA-Sequencing of potassium antimony tartrate (PAT)-treated PBMCs with p53-V272M derived from an AML patient

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Identification of temperature-sensitive (TS) p53 mutations and potassium antimony tartrate (PAT)-treatable p53 mutations in mammalian U937 (free of endogenous p53) cells using a systematic p53 mutation library

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Single-Cell RNA-Sequencing facilitates the effectiveness analysis of clinical-dose arsenic trioxide (ATO) treatment in reactivating V272M in AML patient and in primary AML PBMCs

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Project description:Coronary artery disease (CAD) poses a worldwide health threat. Compelling evidence shows that pericardial adipose tissue (PAT), a brown-like adipose adjacent to the external surface of the pericardium, is associated with CAD. However, the specific molecular mechanisms of PAT in CAD are elusive. For characterizing human PAT and explore its association with CAD, the transcriptome characteristics were assessed in 5 CAD patients and 4 controls via RNA-sequencing.

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Project description:Identification of temperature-sensitive (TS) p53 mutations and potassium antimony tartrate (PAT)-treatable p53 mutations in mammalian U937 (free of endogenous p53) cells using a systematic p53 mutation library

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RNA-seq analysis determined the effect of pat or cobB mutation on transcriptional levels in Salmonella Typhimurium 14028s.

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