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Single-Cell RNA-Sequencing of potassium antimony tartrate (PAT)-treated PBMCs with p53-V272M derived from an AML patient

ABSTRACT: Single-Cell RNA-Sequencing of potassium antimony tartrate (PAT)-treated PBMCs with p53-V272M derived from an AML patient

PROVIDER: PRJNA728462 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14476397_1.fastq.gz	Fastqsanger.gz
	SRR14476397_2.fastq.gz	Fastqsanger.gz
	SRR14476398_1.fastq.gz	Fastqsanger.gz
	SRR14476398_2.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of mutant p53 rescued by potassium antimony tartrate (PAT)

Project description:Transcriptome analysis of mutant p53 rescued by potassium antimony tartrate (PAT)

| PRJNA728694 | ENA

Single-Cell RNA-Sequencing of potassium antimony tartrate (PAT)-treated PBMCs with p53-V272M derived from an AML patient

Project description:The goals of this study are to compare transcriptome of p53-V272M rescued by PAT in primary AML PBMCs

2022-05-02 | GSE174125 | GEO

Transcriptome analysis of mutant p53 rescued by potassium antimony tartrate (PAT)

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Identification of temperature-sensitive (TS) p53 mutations and potassium antimony tartrate (PAT)-treatable p53 mutations in mammalian U937 (free of endogenous p53) cells using a systematic p53 mutation library

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Project description:To identified TS p53 mutations and PAT-treatable p53 mutations in mammalian U937 cells.

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Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani. The antimony resistant and sensitive Leishmania donovani were grown in complete M199 medium with 10% FCS and Penicillin streptomycin mixture. At stationary phase (5 day culture) cells were harvested in sterile Phosphate buffered saline and used for RNA isolation.

2016-07-03 | E-GEOD-62468 | biostudies-arrayexpress

Setaria viridis strain:PAT-5 | cultivar:PAT-5

Project description:Setaria viridis strain:PAT-5 | cultivar:PAT-5 Genome sequencing

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Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

Project description:The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. infantum. Keywords: drug resistance

2009-08-15 | GSE16965 | GEO

Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

2009-08-15 | E-GEOD-16965 | biostudies-arrayexpress

GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis

Project description:Background: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. Genomic analysis has been performed primarily with Old World Leishmania species and here we investigate molecular alterations in antimony resistance in the New World species L. amazonensis. Methods/Principal Findings: We selected populations of L. amazonensis for resistance to antimony by step-wise drug pressure. Gene expression of highly resistant mutants was studied using DNA microarrays. RNA expression profiling of antimony-resistant L. amazonensis revealed the overexpression of genes involved in drug resistance including the ABC transporter MRPA and several genes related to thiol metabolism. The MRPA overexpression was validated by quantitative real-time PCR and further analysis revealed that this increased expression was correlated to gene amplification as part of extrachromosomal linear amplicons in some mutants and as part of supernumerary chromosomes in other mutants. The expression of several other genes encoding hypothetical proteins but also nucleobase and glucose transporter encoding genes were found to be modulated. Conclusions/Significance: Mechanisms classically found in Old World antimony resistant Leishmania were also highlighted in New World antimony-resistant L. amazonensis. These studies were useful to the identification of resistance molecular markers.

2011-06-11 | GSE26159 | GEO

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