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Global and p53-dependent transcriptional response of fibroblasts to Klebsiella pneumoniae

ABSTRACT: Increasing evidence highlights the role of bacteria in the physiopathology of cancer. However, the underlying molecular mechanisms remains poorly understood. Several cancer-associated bacteria have been shown to produce toxins which modulate the tumor suppressor p53 and thereby interfere with the host defense against tumorigenesis. Here, we show that lipopolysaccharides from Klebsiella pneumoniae (Kp) strongly inhibit the host p53 pathway and impairs p53 transcriptional activity upon DNA damage and oncogenic stress, preventing its tumor suppressive function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174531 | GEO | 2022/02/26

REPOSITORIES: GEO

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Genome-wide identification of RNA polymerase, RpoD, and RpoS binding sites in Klebsiella pneumoniae MGH 78578

Project description:Genome-wide identification of RNA polymerase (RNAP) binding sites were performed in Klebsiella pneumoniae MGH 78578 (KP). Anti-RNAP is used to capture the RNAP in KP. ChIP-chip was performed on tiling array specifically made for KP. Comparison ChIP by anti-RNAP antibody vs ChIP by normal mouse IgG (control, mock IP)

2012-12-31 | E-GEOD-35927 | biostudies-arrayexpress

Genome-wide identification of RNA polymerase, RpoD, and RpoS binding sites in Klebsiella pneumoniae MGH 78578

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