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Transcriptional profiling of Regulatory T (Treg) cells in obesity

ABSTRACT: We reported transcriptional characterization of vTreg53 TCR transgenic Treg cells from splenic and visceral adipose tissue (VAT) in mice fed with normal chow diet (NCD) or high fat diet (HFD) for different durations. We also reported transcriptional profile of VAT Treg cells stimulated by IFNa in vitro. Through this analysis, we found that the reduction of VAT Treg cells during obesity is driven by increased production of IFNa in VAT.

ORGANISM(S): Mus musculus

PROVIDER: GSE174706 | GEO | 2021/05/20

REPOSITORIES: GEO

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