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Gene expression profiles analyzed using integrating RNA sequencing and microarray reveals increased inflammatory

ABSTRACT: Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limitsitseffective therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE175626 | GEO | 2021/07/14

REPOSITORIES: GEO

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Gene expression profiles analyzed using integrating RNA sequencing and microarray reveals increased inflammatory response, proliferation, and osteoclastogenesis in pigmented villonodular synovitis

Project description:Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limitsitseffective therapy.

2021-07-14 | GSE176133 | GEO

Arthritis_RA_OA_VNS

Project description:Pigmented villonodular synovitis (PVNS) represents a rare group of lesions with morphological features suggesting an inflammatory as well as a neoplastic nature. Rheumatoid arthritis (RA) is characterized by a chronic inflammation of the synovial tissue and a tumor-like proliferation (TLP) of synovial stroma cells. Osteoarthritis (OA) shows modest inflammatory infiltrates and no TLP. All three diseases result in a progressive destruction of affected joints and remain a diagnostic difficulty because of nonspecific symptoms. This study aimed to identify molecular markers and genes correlated with the development of RA, OA, and PVNS using human whole genome cDNA microarrays and tissue samples obtained from knee surgery. Keywords: disease state analysis

2006-06-06 | GSE3698 | GEO

Transcription profiling of human enosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) samples

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