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Modeling pancreatic beta cell senescence by induction of DNA double-strand breaks

ABSTRACT: Pancreatic beta cell senescence occurs during the development of Type 1 Diabetes. To model the transcriptional responses of islet cells to DNA damage, we previously developed a human islet culture model in which the DNA damage response and senescence can be induced via double strand-breaks with the agent bleomycin. Here, we report the transcriptome-wide changes in human pancreatic islet cells following bleomycin exposure.

ORGANISM(S): Homo sapiens

PROVIDER: GSE176324 | GEO | 2021/06/08

REPOSITORIES: GEO

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