Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE178526 | GEO | 2021/10/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scRNA-seq]

Project description:Cell cycle (CC) is a fundamental biological process with robust, cyclical gene expression programs to facilitate cell division. In the immune system, a productive immune response requires the expansion of pathogen-responsive cell types, but whether CC also confers unique gene expression programs that inform the subsequent immunological response remains unclear. Here we demonstrate that single macrophages adopt different plasticity states in CC which is a major source of heterogeneity in response to polarizing cytokines. Specifically, macrophage plasticity to interferon gamma (IFNG) is substantially reduced, while interleukin 4 (IL-4) can induce S-G2/M-biased gene expression. Additionally, IL-4 polarization shifts the CC-phase distribution of the population towards G2/M phase, providing a mechanism for reduced IFNG-induced repolarization. Finally, we show that macrophages express tissue remodeling genes in the S-G2/M-phases of CC, that can be also detected in vivo during muscle regeneration. Therefore, CC defines macrophage inflammatory and regenerative responses in a cyclical, CC-phase-dependent manner.

2021-10-01 | GSE178525 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [RNA-seq]

2021-10-01 | GSE178523 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scATAC-seq]

2021-10-01 | GSE178524 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

2021-10-01 | GSE178522 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

| PRJNA739496 | ENA

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scATAC-seq]

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scATAC-seq]

| PRJNA739500 | ENA

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

| PRJNA739498 | ENA

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [RNA-seq]

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [RNA-seq]

| PRJNA739499 | ENA

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scRNA-seq]

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scRNA-seq]

| PRJNA739501 | ENA

Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state.

Project description:Cell cycle (CC) facilitates cell division via robust, cyclical gene expression. Protective immunity requires the expansion of pathogen-responsive cell types, but whether CC confers unique gene expression programs that direct the subsequent immunological response remains unclear. Here, we demonstrate that single macrophages (MFs) adopt different plasticity states in CC, which leads to heterogeneous cytokine-induced polarization, priming, and repolarization programs. Specifically, MF plasticity to interferon gamma (IFNG) is substantially reduced during S-G2/M, whereas interleukin 4 (IL-4) induces S-G2/M-biased gene expression, mediated by CC-biased enhancers. Additionally, IL-4 polarization shifts the CC-phase distribution of MFs toward the G2/M phase, providing a subpopulation-specific mechanism for IL-4-induced, dampened IFNG responsiveness. Finally, we demonstrate CC-dependent MF responses in murine and human disease settings in vivo, including Th2-driven airway inflammation and pulmonary fibrosis, where MFs express an S-G2/M-biased tissue remodeling gene program. Therefore, MF inflammatory and regenerative responses are gated by CC in a cyclical, phase-dependent manner.

| S-EPMC9831293 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data