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Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE178561 | GEO | 2021/06/24

REPOSITORIES: GEO

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Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity II

Project description:Hyperglycemia-induced damage to bone formations and function has been recognized.However, as the largest connective tissue organ, whether bone and osteocytes in turn regulate blood sugar and insulin sensitivity has not been addressed. Here we identified a novel protein termed intraflagellar transport 140 with functional importance in regulating osteogenesis, which is also related to the osteoblastic insulin sensitivity. We established Ift140 osteoblastic conditional knockout mice model, and found that blood glucose metabolism could be regulated through osteoblastic IFT140 interacting with O-GlcNAc transferase to regulate insulin signaling. The discovery provides new insight for two-way regulation between bone and glucose metabolism, and also exploring potential new target for blood glucose interventions.

2021-06-24 | GSE178558 | GEO

Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I

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Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity

Project description:Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity

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Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity II

Project description:Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity II

| PRJNA739660 | ENA

Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I

Project description:Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I

| PRJNA739643 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery

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Cross-species Gene Expression Analysis Identifies a Novel Set of Genes Implicated in Human Insulin Sensitivity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Ablation of adipocyte BCL6 enhances subcutaneous adiposity and insulin sensitivity

Project description:This SuperSeries is composed of the SubSeries listed below.

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Intraflagellar Transport and Ciliary Dynamics.

Project description:Cilia and flagella are microtubule-based organelles whose assembly requires a motile process, known as intraflagellar transport (IFT), to bring tubulin and other components to the distal tip of the growing structure. The IFT system uses a multiprotein complex with components that appear to be specialized for the transport of different sets of cargo proteins. The mechanisms by which cargo is selected for ciliary import and transport by IFT remain an area of active research. The complex dynamics of cilia and flagella are under constant regulation to ensure proper length control, and this regulation appears to involve regulation at the stage of IFT injection into the flagellum, as well as regulation of flagellar disassembly and, possibly, of cargo binding. Cilia and flagella thus represent a convenient model system to study how multiple motile and signaling pathways cooperate to control the assembly and dynamics of a complex cellular structure.

| S-EPMC5334256 | biostudies-literature

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