Transcriptomics

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HPV16 E7 expression effect on expression profile mediated by tumor necrosis factor


ABSTRACT: Acute expression of E7 oncogene from HPV-16 or HPV-18 is sufficient to overcome tumor necrosis factor-alfa (TNF) cytostatic effect on primary human keratinocytes. In the present study we investigated the molecular basis of E7-induced TNF resistance through a comparative analysis of the effect of this cytokine on the proliferation and global gene expression of organotypic cultures of normal and E7(wild type or mutant)-expressing keratinocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE17892 | GEO | 2010/01/15

SECONDARY ACCESSION(S): PRJNA120079

REPOSITORIES: GEO

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