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DNA methylation profiles of human primed and naive pluripotent stem cells

ABSTRACT: We introduce a method for generating transgene-free and high-quality naive human induced pluripotent stem cells (iPSCs) using a modified Sendai virus (SeV) vector reprogramming system. This reprogramming method realizes the derivation of naive iPSCs from various somatic cells accompanied with fast and robust SeV vector removal at early passages. The established naive iPSCs have superior naive-specific differentiation ability compared with iPSCs derived from conventional methods.

ORGANISM(S): Homo sapiens

PROVIDER: GSE179473 | GEO | 2022/12/15

REPOSITORIES: GEO

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