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IFT20 is important for effector function of CD4+ T cell

ABSTRACT: Recent studies have suggested that formation of supramolecular activation cluster (SMAC), a large ‘immunological synapse’ composed of various signaling complexes, enhances CD4+ T cell activation. Critically, although the composition of SMAC is known, the proteins involved in SMAC formation have not been fully investigated. We identified that intraflagellar transport 20 (IFT20) play central roles in the effector functino of CD4+ T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE179623 | GEO | 2022/07/31

REPOSITORIES: GEO

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Deficiency of IFT20 in CD4+ T cell alleviates protease-induced neutrophilic asthma-like inflammation

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