Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE179775 | GEO | 2022/04/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179723 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179773 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179725 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179724 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

| PRJNA744924 | ENA

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

| PRJNA744774 | ENA

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

| PRJNA744776 | ENA

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

| PRJNA744928 | ENA

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

| PRJNA744775 | ENA

Tcf1 and Lef1 provide constant supervision to mature CD8<sup>+</sup> T cell identity and function by organizing genomic architecture.

Project description:T cell identity is established during thymic development, but how it is maintained in the periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8+ T cells aberrantly induces genes from non-T cell lineages. Using high-throughput chromosome-conformation-capture sequencing, we demonstrate that Tcf1/Lef1 are important for maintaining three-dimensional genome organization at multiple scales in CD8+ T cells. Comprehensive network analyses coupled with genome-wide profiling of chromatin accessibility and Tcf1 occupancy show the direct impact of Tcf1/Lef1 on the T cell genome is to promote formation of extensively interconnected hubs through enforcing chromatin interaction and accessibility. The integrative mechanisms utilized by Tcf1/Lef1 underlie activation of T cell identity genes and repression of non-T lineage genes, conferring fine control of various T cell functionalities. These findings suggest that Tcf1/Lef1 control global genome organization and help form intricate chromatin-interacting hubs to facilitate promoter-enhancer/silencer contact, hence providing constant supervision of CD8+ T cell identity and function.

| S-EPMC8494933 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data