Transcriptomics

Dataset Information

0

Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis


ABSTRACT: We applied single nuclei and single cell transcriptomics methods to model interneuron development with interneurons derived from human PSCs. We find that PSC-derived interneurons capture stages of development prior to mid gestation, but only represent a minority of potential subtypes that are found in the brain. Comparison of these interneurons to those found in the adult brain highlighted decreased expression of synapse-related genes, reflective of their electrophysiological immaturity. Together, these analyses provide a full characterization of PSC-derived interneurons.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180132 | GEO | 2021/07/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-08-01 | GSE221994 | GEO
2022-12-13 | PXD031193 | Pride
2018-07-03 | GSE116484 | GEO
2022-08-06 | GSE210477 | GEO
2018-10-12 | GSE119998 | GEO
2023-01-12 | GSE222383 | GEO
2016-01-15 | GSE69560 | GEO
2020-07-16 | GSE100300 | GEO
2019-01-24 | GSE121215 | GEO
2017-03-06 | GSE95696 | GEO