Transcriptomics

Dataset Information

0

Microarray analysis of isoginkgetin-treated HCT116 and HCT116p53-/- cells


ABSTRACT: Isoginkgetin (IGG) is a small molecule inhibitor of the spliceosome although the direct target remains elusive. Widespread failure to accurately remove introns poses a risk to cells and organisms through the potential production of aberrant mRNAs and proteins. The cellular responses to accumulation of these intermediates and/or the direct interference of spliceosome assembly itself may constitute a splicing stress but this is not well defined yet. We used oligonucleotide microarrays to assess genome wide changes in gene expression associated with exposure to IGG in HCT116 cells and an isogenic subline lacking the p53 tumor suppressor that responds to a variety of transcriptional stresses (Oncogene 18 (3), 583-592). Two of the 3 enriched pathways identified using PANTHER analysis of differentially expressed transcripts are linked to the ATF4 transcription factor and these effects are p53-independent.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180623 | GEO | 2021/07/23

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-10-09 | GSE249009 | GEO
2023-03-22 | GSE188533 | GEO
2023-03-22 | GSE188534 | GEO
2023-03-22 | GSE202612 | GEO
2016-09-17 | GSE86857 | GEO
2021-03-02 | PXD023019 | Pride
| PRJNA779367 | ENA
2015-11-25 | E-GEOD-73776 | biostudies-arrayexpress
| PRJNA748989 | ENA
2022-11-15 | GSE203561 | GEO