Isoginkgetin induces autophagic cell death in hepatocellular carcinoma [ChIP-seq 2]
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ABSTRACT: Purpose: Our previous studies have identified isoginkgetin as an inducer of autophagic cell death in hepatocellular carcinoma. We set out to analyze how isoginkgetin regulates the genome-wide enhancer activity in HepG2 cells. Methods: ChIP-seqs for H3K4me, H4K8ac, H3K27me3 and H3K9ac were performed in HepG2 followed by treatment with 20 μM isoginkgetin for 24 h. Conclusions: Isoginkgetin treatment reduces the expression of glucose transporters and inhibts SLC2A1 enhancer activity in HepG2 cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE202612 | GEO | 2023/03/22
REPOSITORIES: GEO
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