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Profiling miRNA transcriptomic changes using Affymetrix miRNA4.0 in 6 regions of postmortem brains of subjects with alcohol use disorder

ABSTRACT: Chronic alcohol consumption may alter miRNA transcriptome profiles in reward-related brain regions. Given that miRNAs can regulate the expression of their target coding genes (or mRNAs) at the post-transcriptional level, alcohol-induced miRNA expression change may influence the expression of their targets mRNAs that are involved in alcohol use disorder (AUD)-related pathways, leading to increased risk of AUD. We used the Affymetrix GeneChip™ miRNA 4.0 Array to map miRNA transcriptome profiles in six reward-related regions of postmortem brains of AUD and control subjects and identified differentially expressed miRNAs.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE180700 | GEO | 2021/10/13

REPOSITORIES: GEO

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