Transcriptomics

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Expression from C. elegans L4 animals


ABSTRACT: Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. As predicted, the O-GlcNAc cycling mutants show phenotypically altered lifespan and susceptibility to UV stress.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE18131 | GEO | 2010/01/01

SECONDARY ACCESSION(S): PRJNA123477

REPOSITORIES: GEO

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