Expression from C. elegans L4 animals
Ontology highlight
ABSTRACT: Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. As predicted, the O-GlcNAc cycling mutants show phenotypically altered lifespan and susceptibility to UV stress.
ORGANISM(S): Caenorhabditis elegans
PROVIDER: GSE18131 | GEO | 2010/01/01
SECONDARY ACCESSION(S): PRJNA123477
REPOSITORIES: GEO
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