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Chromatin remodeling governs postnatal maturation in dermal fibroblasts

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE181396 | GEO | 2022/05/17

REPOSITORIES: GEO

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Chromatin remodeling governs postnatal maturation in dermal fibroblasts [scRNA-Seq]

Project description:Tissue stem cells preserve a certain level of potency to maintain intact tissue integrity after various injury. Postnatal dermal fibroblasts lose differentiation potential for regenerative healing that recreates normal tissue including functional hair follicles (HFs), however, their intrinsic cellular changes are not understood yet. Here, we uncover a postnatal maturation process in papillary fibroblasts (PFs) mediated by Twist2-driven chromatin and transcriptional remodeling. Within 4 days after birth, dermal PFs lost WNT transcription factors (TFs) and target gene expressions accompanied by loss of H3K27ac expression. Through single-cell transcriptomics, ATAC-seq and ChIP-seq profiling, we define a postnatal maturation trajectory of PFs, in addition to loss of regenerative trajectory, triggered by decrease of H3K27ac and chromatic accessibility. In vivo inhibition of histone deacetylation delays the postnatal chromatin remodeling and maintains developmental signaling and differentiation potential in PFs. TF motif analysis on the chromatin regions losing accessibility identifies TWIST as a potential regulator specifying these regions. Using Twist2 conditional knock-out mouse model, we unearth a postnatal role of Twist2 TF as governing the postnatal maturation process resulting in switch-off of developmental pathways after birth. Together, our findings expose a comprehensive intracellular mechanism driving postnatal maturation in dermal fibroblasts with profound implications for regenerative medicine.

2022-05-17 | GSE181390 | GEO

Chromatin remodeling governs postnatal maturation in dermal fibroblasts

Project description:Chromatin remodeling governs postnatal maturation in dermal fibroblasts

| PRJNA751875 | ENA

Chromatin remodeling governs postnatal maturation in dermal fibroblasts [ATAC and ChIP]

2022-05-17 | GSE181394 | GEO

Chromatin remodeling governs postnatal maturation in dermal fibroblasts [scRNA-Seq]

Project description:Chromatin remodeling governs postnatal maturation in dermal fibroblasts [scRNA-Seq]

| PRJNA751873 | ENA

Chromatin remodeling governs postnatal maturation in dermal fibroblasts [ATAC and ChIP]

Project description:Chromatin remodeling governs postnatal maturation in dermal fibroblasts [ATAC and ChIP]

| PRJNA751986 | ENA

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-02-04 | E-GEOD-63698 | biostudies-arrayexpress

Multiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Coordinated Chromatin Remodeling induced by Demethylation requires SRCAP mediated H2A.Z exchange

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-01 | E-GEOD-26685 | biostudies-arrayexpress

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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