Transcriptomics

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COX-2 network as predictive molecular marker for clinical pregnancy in IVF


ABSTRACT: CONTEXT Nowadays, the molecular mechanisms involved in endometrial receptivity and implantation are still not clear. OBJECTIVE The gene expression of human endometrium of patients undergoing an IVF treatment with GnRH antagonists/rec-FSH was studied. CONCLUSIONS COX-2 has been extensively studied as a crucial fertility element in both knock-out mice and human. It appears that increased expression of COX-2 and/or SCGB1D2 on the day of oocyte retrieval in GnRH antagonist/rec-FSH stimulated cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle. Keywords: gene expression analysis, clinical pregnancy in IVF stimulated cycles

ORGANISM(S): Homo sapiens

PROVIDER: GSE18140 | GEO | 2010/09/07

SECONDARY ACCESSION(S): PRJNA119429

REPOSITORIES: GEO

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