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Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_I1DN]

ABSTRACT: Investigation of the transcriptional profile of AML in response to DHODH inhibition by AG636. I1DN model was generated by co-transduction of foetal liver derived HSPCs with constructs encoding IDH1R132H, DNMT3AR882H and NrasG12D. Cells were transplanted into Ptprca recipients. Mice bearing I1DN tumors were treated with AG636 for one day. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated and RNA sequencing performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE181663 | GEO | 2022/04/26

REPOSITORIES: GEO

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