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Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_RUNX1]

ABSTRACT: Investigation of the transcriptional profile of AML in response to DHODH inhibition by AG636. RUNX1-RUNX1T1 cells were transplanted into Ptprca recipients. Mice bearing tumors were treated with AG636 for one day. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated and RNA sequencing performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE181664 | GEO | 2022/04/26

REPOSITORIES: GEO

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