Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing analysis of human glioblastoma cell line U87MG treated with LMO2 overexpression.

ABSTRACT: To understand the changes in the expression of genes in U87MG cells due to LMO2, we analyzed the transcriptome of U87MG cells overexpressing LMO2. As a result, we identify differentially expressed genes patterns so that the signaling mechanism regulated by LMO2 in GBM and changes in cells were observed. These RNA sequencing analysis results enable an understanding of the signaling mechanism by LMO2 in GBM.

ORGANISM(S): Homo sapiens

PROVIDER: GSE182169 | GEO | 2022/07/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

mRNA expression profiling (QuantSeq3' mRNA) analysis of human glioblastoma cell line U87MG treated with ID Family (ID1, ID2, ID3, and ID4) overexpression

Project description:To understand the changes in the expression of genes in U87MG cells due to ID Family, we analyzed the transcriptome of U87MG cells overexpressing ID Family. As a result, we identify differentially expressed genes patterns so that the signaling mechanism regulated by ID Family in GBM and changes in cells were observed. These mRNA expression profiling analysis results enable an understanding of the signaling mechanism by ID Family in GBM.

2022-07-13 | GSE182670 | GEO

Human LMO2 binding protein LC-MSMS in U87MG(Glioblastoma cell)

Project description:To identify the binding partner of LMO2 for explanation of STAT3 signal-related protein in human glioblastoma

2022-08-11 | PXD028254 | Pride

Establishment of radioresistant U87MG glioblastoma cell line

Project description:To explore factors contributing to radioresistance in GBM, we established GBM radioresistant cell line using U87MG human GBM cells.

2022-06-29 | GSE207002 | GEO

RNA sequencing analysis of human glioblastoma cell line U87MG treated with LMO2 overexpression.

Project description:RNA sequencing analysis of human glioblastoma cell line U87MG treated with LMO2 overexpression.

| PRJNA755253 | ENA

RNA seq NVP-BEZ235 treatment of U87MG cells

Project description:Glioblastoma (GBM) is the most lethal primary brain cancer that lacks effective molecular targeted therapies. PI3K/AKT/mTOR signaling pathway is activated in 90% of all Glioblastoma Multiforme (GBM) tumors. To gain insight into the impact of the PI3K Pathway on GBM metabolism, we treated U87MG GBM cells with 50nM NVP-BEZ235 (PI3K and mTOR a dual inhibitor) for four days and identified differentially expressed genes with RNA-seq analysis.

2021-12-01 | GSE179667 | GEO

Transcriptome analysis of ABCB7 overexpressed U87MG glioblastoma cells

Project description:This study investigated the biological function of ABCB7 in U87MG glioblastoma cell line. Many ABC transporters are known contributions to drug resistance and various biological process. However, mitochondrial ABC transporters aren’t known mechanism to control biological process. We identified the potential roles of ATP-binding cassette (ABC) transporter subfamily member 7 (ABCB7), one of the mitochondrial ABC transporters. ABCB7 activates signaling pathway of hypoxia-inducible factor 1 alpha (HIF1α) by hypoxia independent regulation. This signaling pathway regulates the death inhibitory genes and survival related genes. Also, ABCB7 downregulates cell cycle related genes. Our results provide that ABCB7 is essential for the survival of malignant brain tumors.

2020-01-01 | GSE120627 | GEO

Transcriptome analysis of CD133 overexpressed U87MG glioblastoma cells

Project description:This study investigated the biological function of CD133 by ectopic expression of CD133 in U87MG cell line. Although CD133 is widely used as a cancer stem cell marker, there are a few studies that examined its own biological functions. While a number of loss-of-function studies about CD133 have shown that CD133 have effects on cancer progression, there are few gain-of-function studies about functions of CD133. Thus, we identified the potential function of CD133 by its overexpression in U87MG glioblastoma cell line. Though there were no significant changes in cell growth and sphere forming ability, elevated IL-1β and its downstream chemokines (CCL3, CXCL3, CXCL5) may function as chemoattractants which affect recruitment of Ly6G+ neutrophils surrounding necrotic regions in vivo and migration of neutrophil-like dHL-60 cells. Taken together, this results imply that CD133 can regulate IL-1β signaling, and promotes the environmental change.

2017-08-03 | GSE99385 | GEO

Expression data from U87MG cells expressing EGFRvIII

Project description:EGFRvIII is the most common deletion mutant of EGFR in human cancer and its levels are highly correlated with poor prognosis in GBM. The deletion of exons 2-7 removes most of the extracellular ligand binding domain, so it is unable to bind EGF or other EGFR-binding ligands. Nevertheless, the mutant receptor is constitutively phosphorylated, and is capable of activating downstream signaling pathways at a low level. To comprehensively identify the downstream signaling consequences of the EGFRvIII, we incorporated phosphoproteomic, transcription profiling and DNase-Seq data from U87MG glioblastoma cells expressing titrated levels of this mutant receptor. Total RNA were extracted from U87MG cells engineered to expressed different levels of EGFRvIII: medium (U87M; 1.5 million copies of EGFRvIII receptor per cell), high (U87H; 2 million copies per cell), super-high (U87SH; 2.5 million copies per cell), and kinase-dead EGFRvIII (U87DK; 2 million copies of kinase dead EGFRvIII per cell). RNA was hybridized to Affymetrix microarrays.

2013-01-01 | E-GEOD-36901 | biostudies-arrayexpress

Expression data from U87MG cells expressing EGFRvIII

2013-01-01 | GSE36901 | GEO

HOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)

Project description:Assess gene expression patterns upon HOXA9 ectopic expression in U87MG GBM cell line and hTERT/E6/E7 immortalized human astrocytes, and HOXA9 silencing in U251 and GBML18 GBM cell lines.

2015-01-30 | GSE56517 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data