Expression data from AFB1-treated GNMT knockout mice

ABSTRACT: We report that liver nodules from 5/8 (62.5%) male and 4/5 (80%) female Gnmt-/- mice were diagnosed as having HCC. Microarray analysis showed that genes involved in the following pathways were deregulated in different stages of tumorigenesis: Methylation, metabolism, signal transduction, cell proliferation, and cell adhesion. This study reveals that GNMT plays an important role in the prevention of hepatotumorigenesis through regulating detoxification pathways. We postulate that GNMT is a stress-responsive protein and its expression may account for the gender difference of the susceptibility to liver cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE18218 | GEO | 2009/10/02

SECONDARY ACCESSION(S): PRJNA119643

REPOSITORIES: GEO