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Differentially expressed and translated genes regulated by PM2.5 exposure in BEAS-2B cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE182201 | GEO | 2022/07/27

REPOSITORIES: GEO

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Next Generation Sequencing identifies differentially translated genes regulated by PM2.5 exposure in BEAS-2B cells [Ribo-seq]

Project description:We report the application of Ribosome sequencing for high-throughput profiling of tanslation efficiency in BEAS-2B cells after exposure to PM2.5.

2022-07-27 | GSE182200 | GEO

Differentially expressed and translated genes regulated by PM2.5 exposure in BEAS-2B cells

Project description:Differentially expressed and translated genes regulated by PM2.5 exposure in BEAS-2B cells

| PRJNA755294 | ENA

Next Generation Sequencing identifies differentially expressed genes regulated by PM2.5 exposure in BEAS-2B cells [RNA-seq]

Project description:We report the application of RNA-sequencing for high-throughput profiling of transcriptomes in BEAS-2B cells after exposure to PM2.5 for 24 hours..

2022-07-27 | GSE182199 | GEO

Next Generation Sequencing identifies differentially translated genes regulated by PM2.5 exposure in BEAS-2B cells [Ribo-seq]

Project description:Next Generation Sequencing identifies differentially translated genes regulated by PM2.5 exposure in BEAS-2B cells [Ribo-seq]

| PRJNA755296 | ENA

Next Generation Sequencing identifies differentially expressed genes regulated by PM2.5 exposure in BEAS-2B cells [RNA-seq]

Project description:Next Generation Sequencing identifies differentially expressed genes regulated by PM2.5 exposure in BEAS-2B cells [RNA-seq]

| PRJNA755295 | ENA

Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation.

Project description:Long-term exposure to fine particulate matter (PM2.5) has been reported to be closely associated with the increased lung cancer risk in populations, but the mechanisms underlying PM-associated carcinogenesis are not yet clear. Previous studies have indicated that aberrant epigenetic alterations, such as genome-wide DNA hypomethylation and gene-specific DNA hypermethylation contribute to lung carcinogenesis. And silence or mutation of P53 tumor suppressor gene is the most prevalent oncogenic driver in lung cancer development. To explore the effects of PM2.5 on global and P53 promoter methylation changes and the mechanisms involved, we exposed human bronchial epithelial cells (BEAS-2B) to low concentrations of PM2.5 for 10 days. Our results indicated that PM2.5-induced global DNA hypomethylation was accompanied by reduced DNMT1 expression. PM2.5 also induced hypermethylation of P53 promoter and inhibited its expression by increasing DNMT3B protein level. Furthermore, ROS-induced activation of Akt was involved in PM2.5-induced increase in DNMT3B. In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis.

| S-EPMC4991485 | biostudies-literature

RNA-seq analysis identifies differentially expressed genes regulated by PM2.5 exposure on HNEpC cells

Project description:In this study, we performed high-throughput sequencing to evaluate the gene expression profiles of Human Nasal Epithelial Cells (HNEpC) (C-12620, PromoCell, Heidelberg, Germany) after exposure to PM2.5 for 24 hours.

2022-12-06 | GSE220165 | GEO

Microarray Analysis of Differentially Expressed Genes in human bronchial cells(BEAS-2B) treated MTX

Project description:Methotrexate (MTX) has been widely used for the treatment of a variety of tumors as well as for inflammatory diseases and rheumatoid arthritis (RA). MTX-induced toxicity has been a serious unpredictable side effect of the treatment and an important clinical problem. Possible causes include allergic, cytotoxic or immunologic reactions to this agent. We examined the consequences of the mechanism of MTX-induced pulmonary toxicity gene expression in BEAS-2B cells, huma bronchial cell line, by microarray. The expression of these genes are potential biomarker of methotrexate-induced pulmonary toxicity. Also, We provide a clue about mechanism of pulmonary toxic action by these clinical chemotherapeutic agents. Keywords: 48h treatment, 0.144uM (dose), MTX

2008-12-06 | GSE9815 | GEO

Gene expression data from BEAS-2B cells upon exposure to particulate matter (PM2.5) from biomass combustion

Project description:Exposure to PM2.5 affects gene expression of BEAS-2B cells Gene expression microarrays were used to detail changes in the transcriptome upon exposure to PM2.5

2020-10-03 | GSE158954 | GEO

Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer.

Project description:BackgroundBreast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal of this research was to determine which genes and pathways are dysregulated in breast cancer when their promoters are methylated in an abnormal way, leading to differential expression. Whole-genome bisulfite sequencing was applied to analyze DMRs for eight peripheral blood samples collected from five Saudi females diagnosed with stages I and II of breast cancer aligned with three normal females. Three of those patients and three normal samples were used to determine differentially expressed genes (DEG) using Illumina platform NovaSeq PE150.ResultsBased on ontology (GO) and KEGG pathways, the analysis indicated that DMGs and DEG are closely related to associated processes, such as ubiquitin-protein transferase activity, ubiquitin-mediated proteolysis, and oxidative phosphorylation. The findings indicated a potentially significant association between global hypomethylation and breast cancer in Saudi patients. Our results revealed 81 differentially promoter-methylated and expressed genes. The most significant differentially methylated and expressed genes found in gene ontology (GO) are pumilio RNA binding family member 1 (PUM1) and zinc finger AN1-type containing 2B (ZFAND2B) also known as (AIRAPL).ConclusionThe essential outcomes of this study suggested that aberrant hypermethylation at crucial genes that have significant parts in the molecular pathways of breast cancer could be used as a potential prognostic biomarker for breast cancer.

| S-EPMC10332364 | biostudies-literature

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