RNA sequencing data of CT26-shppp2r1a and CT26-scr samples
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ABSTRACT: Goal: Microsatellite-instable (MSI) tumors are one of the few cancers that respond to immune checkpoint blockade (ICB); however, the mechanism of MSI status development is unclear. Here, we report that protein phosphatase 2A (PP2A) deletion or inactivation converted cold microsatellite-stable (MSS) into MSI tumors. Objectives: Using RNA sequencing data of three CT26-shppp2r1a data and a CT26-scr data, we demonstrate that these intestinal tumors display differential core driver pathways.
ORGANISM(S): Mus musculus
PROVIDER: GSE182571 | GEO | 2021/08/26
REPOSITORIES: GEO
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