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Identification of genes involved in germline regeneration in adult undifferentiated spermatogonia following a low dose busulfan treatment

ABSTRACT: Mammalian spermatogenesis and male fertility are sustained by a small population of spermatogonial stem cells (SSCs) in the testis. In particular, germ cells are highly sensitive to chemotherapies and radiation, placing male cancer patients at a higher risks of treatment-induced infertility. While SSCs surive the treatment may restore the germline and ferility, it remains unknown how SSCs mediate the regenerative responses to re-establish the germline. In this study, we used a mouse model of chemotherapy-induced germline damage and recovery to identify differentially expressed genes in homeostatic (from untreated control mice) versus regenerative SSCs (busulfan-treated mice) and potential effectors driving the initiation of regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE182727 | GEO | 2022/03/04

REPOSITORIES: GEO

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