Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of genes involved in germline regeneration in adult undifferentiated spermatogonia following a low dose busulfan treatment

ABSTRACT: Identification of genes involved in germline regeneration in adult undifferentiated spermatogonia following a low dose busulfan treatment

PROVIDER: PRJNA757624 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15607106_1.fastq.gz	Fastqsanger.gz
	SRR15607106_2.fastq.gz	Fastqsanger.gz
	SRR15607107_1.fastq.gz	Fastqsanger.gz
	SRR15607107_2.fastq.gz	Fastqsanger.gz
	SRR15607108_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Differentially expressed genes in undifferentiated spermatogonia at single cell level following a low dose of busulfan

Project description:Differentially expressed genes in undifferentiated spermatogonia at single cell level following a low dose of busulfan

| PRJNA758363 | ENA

Differentially expressed genes in undifferentiated spermatogonia at single cell level following a low dose of busulfan

Project description:Spermatogonial stem cells are responsible for sustaining gametes production and male fertiliy in men. However, germ cells including SSCs are highly sensitive to chemotherapies and radiations, placing male cancer patients at high risk of treatment-induce infertility. We have previously shown that the undifferentiated spermatogonial population of mouse testis is functionally heterogeneous and contain both stem cells and committed progenitor cells. Using mouse model of chemotherapy-induced germline damage and recovery, we aim to define molecular charactersitics, dynamics and heterogeneity of undifferentiated spermatogonia during germline regeneration compared to homeostatic undifferentiated spermatogonia.

2022-03-04 | GSE182924 | GEO

Identification of genes involved in germline regeneration in adult undifferentiated spermatogonia following a low dose busulfan treatment

Project description:Mammalian spermatogenesis and male fertility are sustained by a small population of spermatogonial stem cells (SSCs) in the testis. In particular, germ cells are highly sensitive to chemotherapies and radiation, placing male cancer patients at a higher risks of treatment-induced infertility. While SSCs surive the treatment may restore the germline and ferility, it remains unknown how SSCs mediate the regenerative responses to re-establish the germline. In this study, we used a mouse model of chemotherapy-induced germline damage and recovery to identify differentially expressed genes in homeostatic (from untreated control mice) versus regenerative SSCs (busulfan-treated mice) and potential effectors driving the initiation of regeneration.

2022-03-04 | GSE182727 | GEO

Gene expression in undifferentiated spermatogonia

Project description:Gene expression in undifferentiated spermatogonia

| PRJNA605339 | ENA

DAZL targets in undifferentiated spermatogonia

Project description:DAZL targets in undifferentiated spermatogonia

| PRJNA605338 | ENA

Translational profiling in undifferentiated spermatogonia

Project description:Translational profiling in undifferentiated spermatogonia

| PRJNA605340 | ENA

Gene expression in undifferentiated spermatogonia

Project description:RNA-seq of sorted undifferentiated spermatogonia from synchronized postnatal testes.