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Transcriptional changes to cytotoxic stresses are driven by HSF-activated genes and enhancers [PRO-seq]


ABSTRACT: We utilized precicion run-on sequencing (PRO-seq) to analyze the roles of HSF1 and HSF2 in the reprogramming of transcription under oxidative stress and heat shock. PRO-seq was performed in wild-type (WT), HSF1 knock-out (HSF1 KO) and HSF2 knock-out (HSF2 KO) mouse embryonic fibroblasts (MEFs) that were treated with heat shock (HS) or oxidative stress induced by menadione (MD).

ORGANISM(S): Mus musculus

PROVIDER: GSE183243 | GEO | 2022/06/10

REPOSITORIES: GEO

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