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Studies on a hydrocephalus-causing mutation on Trim71

ABSTRACT: We studies on how a hydrocephalus-causing mutation (R783H) on Trim71 alters Trim71's substrate mRNA binding

ORGANISM(S): Mus musculus

PROVIDER: GSE183715 | GEO | 2022/11/04

REPOSITORIES: GEO

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Studies on a hydrocephalus-causing mutation on Trim71 [RNA-seq]

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A Novel Silent Mutation in the L1CAM Gene causing Fetal Hydrocephalus

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Studies on Trim71 in mouse embryonic stem cells

Project description:We studies on Trim71 regulates mouse embryonic stem cells by identifying the transcriptome-wide RNA targets of Trim71. Moreover, through inhibiting specific Trim71:mRNA interactions, we determined how Trim71 modulate miRNA activity in mouse embryonis cell cells

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TRIM71R595H/R595H mutations and TRIM71-KO in mESC lead to similar transcriptomic changes, which indicate a poised state toward neural differentiation

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Project description:We demonstrate that TRIM71 alters stem cell splicing patterns through modulation of MBNL1 levels.

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