Genomics

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Hepatocellular carcinoma (HCC) in FEAT transgenic mouse


ABSTRACT: Transgenic mice (n= 40) overexpressing FEAT in the thymus, spleen, liver, and lung developed malignant lymphoma (47.5%, 19/40) and liver cancer (hepatocellular carcinoma, HCC) (35%, 14/40). Notably, HCC arose in half (13/26) of the male transgenic mice, indicating a strong male predilection similar to human HCC. Microarray-based comparative genomic hybridization (array-CGH) suggested that HCC in FEAT transgenic mice recapitulates human hepatocarcinogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE18403 | GEO | 2009/10/15

SECONDARY ACCESSION(S): PRJNA118249

REPOSITORIES: GEO

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