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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers (STARRseq)

ABSTRACT: Changes in enhancer activity after chromatin remodeler depletion

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE184186 | GEO | 2022/09/14

REPOSITORIES: GEO

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers.

Project description:Gene transcription is a highly regulated process in all animals. In Drosophila, two major transcriptional programs, housekeeping and developmental, have promoters with distinct regulatory compatibilities and nucleosome organization. However, it remains unclear how the differences in chromatin structure relate to the distinct regulatory properties and which chromatin remodelers are required for these programs. Using rapid degradation of core remodeler subunits in Drosophila melanogaster S2 cells, we demonstrate that developmental gene transcription requires SWI/SNF-type complexes, primarily to maintain distal enhancer accessibility. In contrast, wild-type-level housekeeping gene transcription requires the Iswi and Ino80 remodelers to maintain nucleosome positioning and phasing at promoters. These differential remodeler dependencies relate to different DNA-sequence-intrinsic nucleosome affinities, which favor a default ON state for housekeeping but a default OFF state for developmental gene transcription. Overall, our results demonstrate how different transcription-regulatory strategies are implemented by DNA sequence, chromatin structure, and remodeler activity.

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers (PROseq)

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers (MNase)

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers

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