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In vivo single cell transcriptomics reveals Klebsiella pneumoniae-governed polarization of ontogenetically distinct macrophage lineages by targeting an evolutionary conserved type I IFN-IL10-STAT6 axis to promote infection.

ABSTRACT: Mice were infected with Klebsiella pneumoniae and interstitial and alveolar macrophages isolated and subjected to single cell RNA sequencing to investigate the transcriptomes of Klebseilla-associated and uninfected bystander cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE184290 | GEO | 2022/09/16

REPOSITORIES: GEO

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