Transcriptomics

Dataset Information

0

G3bp1-miR-1 axis regulates cardiomyocyte hypertrophy


ABSTRACT: We examine the role of G3bp1, a RNA binding protein and site specific endoribonuclease in gene expression in isolated neonatal cardiomyocytes. RNAseq data from cardiomyocytes were infected with adenoviruses expressing shRNA against G3bp1 (ad-siG3bp1) or Luciferase (ad-siLUC, control) showed significant decrease in transcript abudnnace of cardiac-enriched genes involved in Calcium handling, contraction, action potential and sacromere function. On the other hand increase was observed in genes that regulate Hippo, TNF and TGFb signaling. Knockdown of G3bp1 inhibited endothelin-1 induced cardiomyocyte hypertrophy.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE184441 | GEO | 2022/01/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA764679 | ENA
2024-08-18 | GSE274650 | GEO
2012-10-01 | E-MEXP-3392 | biostudies-arrayexpress
2021-03-16 | GSE168943 | GEO
2024-04-14 | GSE263539 | GEO
2021-09-26 | GSE138612 | GEO
2023-12-13 | GSE249869 | GEO
2024-10-31 | GSE262032 | GEO
2021-05-07 | GSE173546 | GEO
2023-03-16 | GSE190479 | GEO