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Transcriptome profiling of oxidase knockout mice response to gingival inflammation using RNA-seq

ABSTRACT: Genetic defects in neutrophil function or trafficking are highly associated with oral inflammation and periodontitis. The leukocyte NADPH oxidase enzymes complex is a multi-subunit enzyme that has been described to play important immunomodulatory roles in limiting the inflammatory responses of neutrophils and macrophages. Here, we determined the impact of loss of NADPH oxidase dependent reactive oxygen species (ROS) generation in gingival inflammatory responses using a model of ligature induced murine periodontitis.

ORGANISM(S): Mus musculus

PROVIDER: GSE184556 | GEO | 2024/04/23

REPOSITORIES: GEO

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