Genomics

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Genome-wide HIF-1, RNA polII, and H3K4me3 binding sites in U87 and HepG2 cells


ABSTRACT: Hypoxia-Inducible Factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we used ChIP-chip and gene expression profiling to define the relationship between the epigenetic landscape, sites of HIF-1 binding, and genes transactivated by hypoxia in two cell lines, HepG2 hepatoma cell line and U87 glioma cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18499 | GEO | 2009/10/09

SECONDARY ACCESSION(S): PRJNA123719

REPOSITORIES: GEO

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