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Induction of mouse totipotent stem cells by a defined chemical cocktail [RRBS]

ABSTRACT: We demonstrate induction and long-term maintenance of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs) by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. These cells, which we designated as ciTotiSCs (chemically induced totipotent stem cells), resembled mouse totipotent 2C-embryo stage cells at both transcriptome and epigenome level.

ORGANISM(S): Mus musculus

PROVIDER: GSE185004 | GEO | 2022/05/25

REPOSITORIES: GEO

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