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Induction of mouse totipotent stem cells by a defined chemical cocktail [RRBS]

ABSTRACT: Induction of mouse totipotent stem cells by a defined chemical cocktail [RRBS]

PROVIDER: PRJNA767358 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16117868_1.fastq.gz	Fastqsanger.gz
	SRR16117868_2.fastq.gz	Fastqsanger.gz
	SRR16117869_1.fastq.gz	Fastqsanger.gz
	SRR16117869_2.fastq.gz	Fastqsanger.gz

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Induction of mouse totipotent stem cells by a defined chemical cocktail

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Induction of mouse totipotent stem cells by a defined chemical cocktail [RRBS]

Project description:We demonstrate induction and long-term maintenance of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs) by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. These cells, which we designated as ciTotiSCs (chemically induced totipotent stem cells), resembled mouse totipotent 2C-embryo stage cells at both transcriptome and epigenome level.

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Induction of mouse totipotent stem cells by a defined chemical cocktail [bulk RNA-seq]

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Induction of mouse totipotent stem cells by a defined chemical cocktail

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-25 | GSE185005 | GEO

Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210

Project description:Neural stem cells (NSCs) are valuable for both basic research and clinical application. We previously reported a chemical cocktail that could reprogram somatic cells into neural progenitor cells. However, the process of chemical induction is complex and the underlying mechanism remains largely elusive. Here, we identified a new culture condition that greatly promotes the efficiency of NSC generation directly from mouse fibroblasts based on our reported chemical cocktail. Transcriptome and epigenome analyses during the reprogramming process demonstrated that growth factors including IL6, FGF5 and LIF were dynamically activated and contributed to the chemical cocktail induced cell fate changes. Interestingly, fibroblast-to-NSC conversion requires the synergistic action of these growth factors. Moreover, the reprogramming capacity of both chemical cocktail and growth factors require nucleoporin Nup210 to activate endogenous neural transcription factors SoxB1 family to initiate NSC fate. Our study not only provides a novel protocol to generate NSC directly from mouse fibroblasts, but also reveals an important role of growth factors in chemical-induced cellular reprogramming.

2019-12-31 | GSE108300 | GEO

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