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The effect of lithium and dexamethasone on fetal rat metatarsal bones transcriptome

ABSTRACT: While dexamethasone impairs bone growth and adds to the development of osteoporosis, lithium enhances cell renewal. The aim of this project was to explore the genes and pathways affected by adding dexamethasone, lithium or both to the medium in which fetal rat metatarsal bones were cultivated. RNA sequencing and differential gene expression analysis were implemented to describe the transcriptome of the metatarsals. We identified significant opposite as well as independent effects of the substances on several cellular pathways. This may open up to identify the mechanisms of dexamethasone induced bone growth and structure impairment and possible preventive measures.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE186104 | GEO | 2022/01/01

REPOSITORIES: GEO

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The effect of lithium and dexamethasone on fetal rat metatarsal bones transcriptome

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