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Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity [Zebrafish.scATAC-seq]

ABSTRACT: Using a combination of single-cell multi-omics, lineage tracing and functional assays, we show that embryonic HSPCs are originated from heterogeneous hemogenic endothelial cells (HECs) during zebrafish embryogenesis.

ORGANISM(S): Danio rerio

PROVIDER: GSE186424 | GEO | 2023/06/06

REPOSITORIES: GEO

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Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity

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