Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequence of mRNA after silencing of HGDILnc1 compared to controls.

ABSTRACT: We report a total of 692 downregulated genes and 916 upregulated genes (2-fold) were detected after knockdown of HGDILnc1 in HUVEC cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE186473 | GEO | 2024/03/20

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA microarray of mRNA after after hypoxia or glucose deprivition compared to controls.

Project description:We report a total of 402 upregulated genes and 197 downregulated genes (2-fold) were detected after hypoxia treatment and 386 upregulated genes and 245 downregulated genes (2-fold) were detected after glucose deprivation in HUVEC cells

2024-03-20 | GSE186474 | GEO

RNA sequence of mRNA after silencing of HGDILnc1 compared to controls.

Project description:RNA sequence of mRNA after silencing of HGDILnc1 compared to controls.

| PRJNA773971 | ENA

Transcriptomic analysis of targets regulated by miR-146a in primary endothelial cells

2013-12-21 | GSE43016 | GEO

Transcriptomic analysis of targets regulated by miR-146a in primary endothelial cells

Project description:Human vein umbilical endothelial cells (HUVEC) were transfected with pre-miR control and pre-miR 146 (Ambion) in order to identify targets (direct and indirect) downregulated by miR-146a in endothelial cells. 164 transcripts were downregulated with a fold change ≥ 1.2. Total RNA was obtained from cells transfected in HUVEC with pre-miR control and pre-miR 146a. Three independent transfections were performed for each condition. 2 replicates for control re-control and 3 for pre-miR 146a were analyzed.

2013-12-21 | E-GEOD-43016 | biostudies-arrayexpress

Transcriptomic analysis of targets regulated by miR-125b in primary endothelial cells

Project description:Human vein umbilical endothelial cells (HUVEC) were transfected with pre-miR control and pre-miR 125b (Ambion) in order to identify targets (direct and indirect) downregulated by miR-125b in endothelial cells. 317 transcripts were downregulated with a fold change ≥ 1.5, among which 99 are predicted direct targets of mir-125b. Computional approach performed with Ingenuity Pathway Knowledge shows that movement of cell and cell-to-cell signalling are the top two biological functions affected bewteen control and transfected cells. Experiments performed in zebrafish and in HUVEC confirmed that mir-125b mainly affects genes involved in cellular movements and junctions. Total RNA was obtained from cells transfected in HUVEC with pre-miR control and pre-miR 125b. Three independent transfections were performed for each condition.

2011-04-30 | E-GEOD-21458 | biostudies-arrayexpress

Transcriptomic analysis of targets regulated by miR-125b in primary endothelial cells

2011-04-30 | GSE21458 | GEO

Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing.

Project description:Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate. The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforce gene silencing, but how transcriptional repression is propagated through mitotic cell divisions remains a key unresolved question. Using reversible tethering of PcG proteins to ectopic sites in mouse embryonic stem cells, here we show that PRC1 can trigger transcriptional repression and Polycomb-dependent chromatin modifications. We find that canonical PRC1 (cPRC1), but not variant PRC1, maintains gene silencing through cell division upon reversal of tethering. Propagation of gene repression is sustained by cis-acting histone modifications, PRC2-mediated H3K27me3 and cPRC1-mediated H2AK119ub1, promoting a sequence-independent feedback mechanism for PcG protein recruitment. Thus, the distinct PRC1 complexes present in vertebrates can differentially regulate epigenetic maintenance of gene silencing, potentially enabling dynamic heritable responses to complex stimuli. Our findings reveal how PcG repression is potentially inherited in vertebrates.

| S-EPMC6488670 | biostudies-other

RNAseq analysis in TNF treated HUVEC cells compared to controls

Project description:RNAseq analysis in TNF treated HUVEC cells compared to controls

| PRJEB34248 | ENA

Homo sapiens

Project description:USP22 downregulated in HUVEC cell line Raw sequence reads

| PRJNA722701 | ENA

RNA sequence of mRNA in HUVEC cells after depleting EGFL6

Project description:RNA sequence of mRNA in HUVEC cells after depleting EGFL6

| PRJNA549677 | ENA