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Chromatin accessibility profiles of murine primary bone marrow derived maccrophages treated with LPS or LPS and Dex [ATAC-seq]

ABSTRACT: We mapped the open chromatin regions in wild type LPS and LPS plus Dex treated murine bone marrow derived macrophages (BMDMs).

ORGANISM(S): Mus musculus

PROVIDER: GSE186511 | GEO | 2023/06/23

REPOSITORIES: GEO

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GR and BRG1 cistromes of murine primary bone marrow derived macrophages treated with LPS and Dex+LPS [ChIP-seq]

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Project description:Purpose: The purpose of this study was to compare the BMDMs transcriptome in the control LPS and LPS plus BHB group in order to identify the critical pathway that contributed to the inhibiton of BHB on M1 polarization. Methods: 1× 106 BMDMs were pre-treated with PBS or BHB for 1 hours before LPS administration. Four hours later, BMDMs were harvested for RNA preparation. Results: Among 16650 mapped genes, 7325 differentially expressed genes were identified, including 244 LPS inducible BHB down regulated named class A and 537 LPS repressed BHB up regulated genes named class B. The genes in class A were mainly TLR4 and TNF signaling pathway, while genes in class B were associated with negative regulation of transcription and NF-KB signaling. The GSEA showed that BHB have the similar profiles chnage on BMDMs with TSA. Conclusions: Our study revealed that BHB down regulated TLR4 and NF-KB pathway related genes to inhibited M1 polarization, and BHB have a similar effect on BMDMs with TSA through comparing the genetic changes of two substance caused in cells.

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Project description:Chromatin accessibility profiles of murine primary bone marrow derived maccrophages treated with LPS or LPS and Dex [ATAC-seq]

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