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Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity

ABSTRACT: To study the gene expression changes upon CAF-1 deletion, we performed RNA-seq analyses in isolated HSPCs after 48 hours of Chaf1b deletion.

ORGANISM(S): Mus musculus

PROVIDER: GSE186745 | GEO | 2022/02/20

REPOSITORIES: GEO

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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

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Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity

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Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity

Project description:To study the expression and chromatin profiles upon Hoxa9 inactivation and CAF-1 suppression, we performed ATAC-seq and RNA-seq analyses at 48 hours using Hoxa9-Granulocyte-macrophage progenitor cells (Hoxa9-GMPs).

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Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity

Project description:This SuperSeries is composed of the SubSeries listed below.

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Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity

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Project description:Regulation of Chromatin Accessibility by the Histone Chaperone CAF-1 Sustains Lineage Fidelity