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Transcriptomic profiling of Phactr1 overexpression in human endothelial cells

ABSTRACT: Phactr-1 is an actin and protein phosphatase 1 (PP1) binding protein which is reported to be highly expressed in brain and controls PP1 activity and F-actin remodelling. Genome-wide association studies (GWASs) implicate the Phactr-1 locus (6p24) as a risk factor for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension, with its mechanism of action being incompletely understood. To depict how Phactr1 regulates endothelial cell function, we performed transcriptomic profiling of human umbilical vein endothelial cells (HUVECs) infected with Phactr1 adenovirus. We documented that Phactr1 overexpression triggers multiple aspects of endothelial dysfunction, thus providing a mechanistic basis for Phactr1 mediated disease-relevant vascular functions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186761 | GEO | 2022/08/16

REPOSITORIES: GEO

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